NFL Week 5 Expert Betting Preview | Odds & Tips

NFL Week 5 Expert Betting Preview

NFL Games To Bet On Week 5

NFL Week 5 will have three teams still unbeaten and six that don’t know the taste of victory.

The Detroit Lions and the Miami Dolphins will be on a bye week, but all eyes will be on Jay Gruden and the Washington Redskins.

The youngest of the Grudens could become the first head coach fired this season.

Los Angeles Rams (3-1) vs. Seattle Seahawks (3-1)

Rams vs. Seahawks
+100 Moneyline -125
+1.5 (-110) Spread  -1.5 (-110)
O 49.5 (-110) Total U 49.5 (-110)
Bet On Rams vs. Seahawks NFL Week 5 Game At MyBookie.ag

The top of the NFC West might be at stake on Thursday Night. The people making the odds at MyBookie.ag set this betting line as a PK when it opened, but it has moved to Seahawks -1.5 in the last few hours.

Watching the Rams getting trashed by the Buccaneers on Sunday was eye-opening. The 55 points scored by Tampa Bay is the most Los Angeles has allowed since HC Sean McVay, and DC Wade Phillips teamed up in 2017.

Seattle is 3-1, but their three victories were against teams with a combined record of 1-10-1.

Rams vs. Seahawks Game Information

  • Date: Thursday, October 3, 2019
  • Game Time: 8:20 PM ET
  • Venue: CenturyLink Field, Seattle, WA
  • TV: FOX Sports / NFL Network

Buffalo Bills (3-1) vs. Tennessee Titans (2-2)

Bills vs. Titans
N/A Moneyline N/A
+2.5 (+100) Spread  -2.5 (-120)
O 38.5 (-110) Total U 38.5 (-110)
Bet On Bills vs. Titans NFL Week 5 Game At MyBookie.ag

The betting line for this AFC game opened with Tennessee -1, and it’s now -2.5 at Mybookie.ag.

The Bills won’t have QB Josh Allen after he suffered a concussion during the meeting against the New England Patriots. Matt Barkley will take the field as the starter.

Titans’ QB Marcus Mariota is currently one of the three quarterbacks who has not thrown an interception this season.

Mariota was not sacked in the week four win against Atlanta, and he will get his Pro Bowl LT Taylor Lewan back from suspension.

Bills vs. Titans Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Nissan Stadium, Nashville, TN
  • TV: CBS

Arizona Cardinals (0-3-1) vs. Cincinnati Bengals (0-4)

Cardinals vs. Bengals
+150 Moneyline -180
+3.5 (-120) Spread -3.5 (-180)
O 47 (-110) total U 47 (-110)
Bet On Cardinals vs. Bengals NFL Week 5 Game At MyBookie.ag

One of these teams might record the first win of the season. Unless they realize they are equally weak, and the game finishes tied.

Arizona already has one tie this season, earned in week one against Detroit. Cardinals rookie Kyler Murray is the most sacked QB in the NFL with 20 sacks in four games.

Bengals QB Andy Dalton is second with 19. The Steelers sacked Dalton eight times during Monday Night football.

Cardinals vs. Bengals Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Paul Brown Stadium, Cincinnati, OH
  • TV: FOX

Chicago Bears (3-1) vs. Oakland Raiders (2-2)

Bears vs. Raiders
-5 (-110) Spread +5 (-110)
-220 Moneyline +180
O 40.5 (-110) Total U 40.5 (-110)
Bet On Bears vs. Raiders NFL Week 5 Game At MyBookie.ag

The return of Khalil Mack to Oakland will be the storyline for this game. Mack has recorded 4.5 sacks this season despite getting double-teamed on every snap and many occasions triple-teamed.


The Bears opened at -6, but the line quickly went down a point. Oakland won’t have LB Vontaze Burfict for the rest of the season.

The NFL suspended Burfict for a helmet to helmet on Indy’s TE Jack Doyle. This will be the first game of the season played in London.

Bears vs. Raiders Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Tottenham Hotspur Stadium, London
  • TV: FOX

Tampa Bay Buccaneers (2-2) vs. New Orleans Saints

Buccaneers vs. Saints
 +3.5 (-120) Spread -3.5 (+100)
+155 Moneyline -180/A
O 47.5 (-110) Total U 47.5 (-110)
Bet On Buccaneers vs. Saints NFL Week 5 Game At MyBookie.ag

The Saints are -3.5  at MyBookie. New Orleans -5.5 was the line when it opened, but it has moved after seeing Tampa Bay scored 55 on the Rams during the weekend.

Bucs QB Jameis Winston is coming one of the best games of his career. Winston threw 385 yards and 4 TDs against the Rams. It was the third time in his career when went for 300+ yards and four TDs.

New Orleans has won their last two games against Seattle and Dallas despite averaging just 265.5 total yards in those wins.

Buccaneers vs. Saints Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Mercedes-Benz Superdome, New Orleans, LA
  • TV: FOX

Minnesota Vikings (2-2) at NY Giants (2-2)

Vikings vs. Giants
-6 (+100) Spread +76(-120)
-220 Moneyline +184
O 45 (-110) Total U 45 (-110)
Bet On Vikings vs. Giants NFL Week 5 Game At MyBookie.ag

The betting line for this game has the Vikings -6 on the road despite their passing offense is second-last in the NFL, only behind the Jets. Both Vikings’ losses this season have come on the road.

On Sunday WR Adam Thielen took a shot at his QB Kirk Cousins saying: “at some point, you have to be able to throw the football.” It was music to the ears of Cousins’ haters.

The Giants starting linebacker Ryan Connelly suffered a torn ACL and is done for the season. The team, however, gets WR Golden Tate back from suspension.

Vikings vs. Giants Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: MetLife Stadium, East Rutherford, NJ
  • TV: FOX

NY Jets (0-3) vs. Philadelphia Eagles (2-2)

Jets vs. Eagles
+14 (-120) Spread -14 (+100)
N/A Moneyline N/A
O 44.5 (-110) Total U 44.5 (-110)
Bet On Jets vs. Eagles NFL Week 5 Game At MyBookie.ag

The Jets are coming off a bye week, but that hardly matters as the Eagles had ten days to prepare for this game. Philly opened -15.5, and they are now at -14. It is the second-largest spread of the week.

According to several reports, this is the week when Jets QB Sam Darnold should be back with the team after dealing with mono. However, the doctors nor HC Adam Gase has clear him to play on Sunday.

The Jets are likely to be without LB CJ Mosley and rookie DT Quinnen Williams as well; both are listed doubtful to face the Eagles.

Jets vs. Eagles Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Lincoln Financial Field, Philadelphia, PA
  • TV: CBS

Baltimore Ravens (2-2) at Pittsburgh Steelers (1-3)

Ravens vs. Steelers
-3.5 (-105) Spread +3.5 (-115)
-190 Moneyline +160
O 43.5 (-110) Total U 43.5 (-110)
Bet On Ravens vs. Steelers NFL Week 5 Game At MyBookie.ag

Despite all the hype about Lamar Jackson and the overreaction about the bad start from the Steelers, these two teams are separated just by one game.

The Ravens -3.5 on the road seems a little disrespectful to the Steelers. Baltimore’s defense has allowed 500+ total yards in two consecutive games. It should be a good matchup for Pittsburgh’s RB James Conner.

Ravens vs. Steelers Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Heinz Field, Pittsburgh, PA
  • TV: CBS

New England Patriots (4-0) at Washington Redskins (0-4)

Patriots vs. Redskins
-16 (-110) Spread +16 (-110)
-1300 Moneyline +700
O 43.5 (-110) Total U 43.5 (-110)
Bet On Patriots vs. Redskins NFL Week 5 Game At MyBookie.ag

Who made the schedule this season? Bob Kraft? This is now the third week of the season where the Patriots are favorites by a two-touchdown difference.

The betting line had the Patriots -16.5 when it opened. The oddsmakers at MyBookie.ag dropped it to 16 in the last few hours.

Is this the end for Jay Gruden?

Patriots vs. Redskins Game Information

  •  Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: FedEx Field, Landover, MD
  • TV: CBS

Jacksonville Jaguars (2-2) vs. Carolina Panthers (2-2)

Jaguars vs. Panthers
+3.5 (-115) Spread -3.5 (-105)
+160 Moneyline -190
O 41 (-110) Total U 41 (-110)
Bet On Jaguars vs. Panthers NFL Week 5 Game At MyBookie.ag

There is a battle of backup QBs in Carolina this weekend. Panthers’ QB Kyle Allen has been good, but Gardner Minshew has stolen all the social media talk over the past two weeks.

The Panthers are -3.5 after opening at -4. Both teams started the season 0-2 but have climbed back to .500 with their young QBs playing better than expected.

Carolina hasn’t won’t at home this season. The Panthers are 0-2 at their stadium, although both times they had Cam Newton under center. This is Kyle Allen’s show now.

Jaguars vs. Panthers Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: Bank of America Stadium, Charlotte, NC
  • TV: CBS

Atlanta Falcons (1-3) vs. Houston Texans (2-2)

Falcons vs. Texans
+5 (-110) Spread -5 (-110)
+180 Moneyline -220
O 48.5 (-110) Total U 48.5 (-110)
Bet On Falcons vs. Texans NFL Week 5 Game At MyBookie.ag

Last season Texans QB Deshaun Watson was the most sacked QB in the NFL; this year he’s already third on that list.

Houston listed WR Kenny Stills questionable for this game with a hamstring injury suffered during the weekend.

Atlanta’s defense has the second-fewest sacks in the league with five. Only Philadelphia has recorded less.

Falcons vs. Texans Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 1:00 PM ET
  • Venue: NRG Stadium, Houston, TX
  • TV: FOX

Denver Broncos (0-4) vs. Los Angeles Chargers (2-2)

Broncos vs. Chargers
+6.5 (-110) Spread -6.5 (-110)
+235 Moneyline -285
O 44 (-110) Total U 44 (-110)
Bet On Broncos vs. Chargers NFL Week 5 Game At MyBookie.ag

Broncos QB Joe Flacco is 0-4 for the first-time ins his career. Their offense is averaging only 17.5 points per game during the first month of the season.

On defense, Denver lost OLB Bradley Chubb for the rest of the season with a torn ACL. Before the game against the Jaguars during the weekend, the team had zero sacks in 2019. Without Chubb, the task gets harder.

The Chargers had RB Melvin Gordon back last week against Miami, but he didn’t play a snap. Gordon should see some action against the Broncos.

Broncos vs. Chargers Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 4:05 PM ET
  • Venue: Dignity Health Sports Park, Carson, CA
  • TV: CBS

Green Bay Packers (3-1) vs. Dallas Cowboys (3-1)

Packers vs. Cowboys
+3.5 (-125) Spread -3.5 (+100)
+150 Moneyline -180
O 46.5 (-110) Total U 46.5 (-110)
Bet On Packers vs. Cowboys NFL Week 5 Game At MyBookie.ag

Green Bay and Dallas dropped games as favorites during the weekend.

The Cowboys opened -4.5, but the line has gone down a full point. By the time of the kickoff, the odds should be a field goal difference.

QB Aaron Rodgers has won six of the last seven meetings against Dallas, including two playoffs games.

Packers vs. Cowboys Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 4:25 PM ET
  • Venue: AT&T Stadium, Arlington, TX
  • TV: FOX

Indianapolis Colts (2-2) at Kansas City Chiefs(4-0)

Colts vs. Chiefs
 +11.5 (-110) Spread  -11.5 (-110)
+420 Moneyline  -600
O 56.5 (-110) Total U 56.5 (-110)
Bet On Colts vs. Chiefs NFL Week 5 Game At MyBookie.ag

Last week it was the first time QB Patrick Mahomes didn’t throw a touchdown in his young career since his debut in the league.

WR Tyreek Hill was seen running routes last week, but he is not eligible to return. RB Damien Williams is listed questionable to return to the lineup after missing the game against Detroit with a knee injury.

Colts vs. Chiefs Game Information

  • Date: Sunday, October 6, 2019
  • Game Time: 8:20 PM ET
  • Venue: Arrowhead Stadium, Kansas City, MO
  • TV: NBC

Cleveland Browns (2-2) at San Francisco 49ers (3-0)

Browns vs. 49ers
+3.5 (-115) Spread -3.5 (-105)
+160 Moneyline -200
O 46.5 (-110) Total U 46.5 (-110)
Bet On Browns vs. 49ers NFL Week 5 Game At MyBookie.ag

The Browns finally protected Baker Mayfield last week, and everything changed. Mayfield was sacked 11 times in the first three weeks of the season but only once against Baltimore.

San Francisco is coming off a bye week. The 49ers are the only undefeated team in the NFC, and this is the first time in 21 years the franchise starts 3-0.

MyBookie.ag opened with the 49ers -3 but expect the line to bounce around between -3.5 and a field goal difference.

Browns vs. 49ers Game Information

  • Date: Monday, October 7, 2019
  • Game Time: 8:15 PM ET
  • Venue: Levi’s Stadium, Santa Clara, CA
  • TV: ESPN

Bet On NFL Week 5 Games At MyBookie Sportsbook

mybookie sportsbookMyBookie.ag is one of our top-rated NFL football betting sites. It offers new players a 100% Up To $1,000 on their first deposit.

It is the perfect sportsbook for betting on the NFL, as it offers some of the high betting limits for football. They accept a variety of cashier methods, including several cryptocurrencies.  These are processed for free when making a deposit or requesting a withdrawal.

Alonzo Solano

Alonzo is a Sports Analyst who has covered College Football and NFL odds for SafestBettingSites but don’t be surprised if you read him on any other sport. He’s a gaming analyst looking for winners every weekend.

Join 1,000+ Sports Bettors Who receive our experts' newsletter And never miss a winning sports pick!
Emailed weekly, unsubscribe with a single click.