NFL Week 1 Expert Betting Preview | Odds & Tips

NFl Week 1 Betting Preview & Odds

NFL WEEK 1 GAMES BREAKDOWN

After a bizarre year, the NFL is finally back.

We have enjoyed the NBA & MLB betting, and the occasional hockey, but it’s time to get back in business.

NFL Week 1 will have nine divisional matchups, including the Bucs and Saints’ monster clash. But also two Monday Night Football games.

NFL Week 1 Games & Betting Odds

This is what you need to know about the first weekend of professional football in 2020. Let’s take a look at each of the games.

Houston Texans At Kansas City Chiefs Betting Odds

Houston Texans Vs. Kansas City Chiefs
Houston (+350) Moneyline Kansas City (-440)
+9.5 (-110) Spread -9.5 (-110)
O 54.5 (-110) Total U 54.5 (-110)
Bet On Houston Texans Vs. Kansas City Chiefs NFL Week 1 Game at MyBookie.ag

Texans Vs. Chiefs Game Info:

  • Date: Thursday, September 10, 2020 | 8:20 PM ET
  • Stadium: Arrowhead Stadium, Kansas City, MO
  • TV: NBC

Texans Vs. Chiefs Breakdown

After going down 0-24 in the second quarter of their divisional meeting, the Kansas City Chiefs outscored the Houston Texans 51-7. The rest is history.

The Chiefs will have most of the team that won Super Bowl 54 back. Houston lost WR DeAndre Hopkins. They will try to replace him with a wideout committee between Brandin Cooks, Randall Cobb, Kenny Stills, and Will Fuller V.

The betting opened with the Chiefs -11, but across most sportsbooks, Kansas City is now -9.

Public: 58% is with the Chiefs -9.

Seattle Seahawks At Atlanta Falcons Betting Odds

Seattle Seahawks Vs. Atlanta Falcons
Seattle (-130) Moneyline Atlanta (+110)
-2 (-110) Spread +2 (-110)
O 49 (-110) Total U 49 (-110)
Bet On Seattle Seahawks Vs. Atlanta Falcons NFL Week 1 Game at MyBookie.ag

Seahawks Vs. Falcons Game Info:

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: Mercedes-Benz Stadium, Atlanta, GA
  • TV: FOX

Seahawks Vs. Falcons Breakdown

Both Russell Wilson and Matt Ryan were the most sacked QBs in the NFL in 2019. Neither team tried to improve their offensive lines in the offseason.

Wilson will have TE Greg Olsen, WR Phillip Dorsett, and RB Carlos Hyde as new weapons. Safety Jamal Adams should be a game-changer for the defense.

Atlanta had the third-best passing offense in the NFL in 219. Yet, they were the third-worst running the ball. Adding Todd Gurley should help both departments.

Seattle has received 69% of the bets in this game. They might be -2.5 soon if you don’t take them right now.

Public: 69% is on the Seahawks -2.

NY Jets At Buffalo Bills Betting Odds

New York Jets Vs. Buffalo Bills
Jets (+240) Moneyline Bills (+-280)
+6.5 (-110) Spread -6.5 (-110)
O 39.5 (-110) Total U 39.5 (-110)
Bet On New York Jets Vs. Buffalo Bills NFL Week 1 Game at MyBookie.ag

Jets Vs. Bills Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: Bills Stadium, Orchard Park, NY
  • TV: CBS

Jets Vs. Bills Breakdown

The Jets traded S Jamal Adams, and LB CJ Mosley opted out. Both were captains on the team last season.

Last year New York had the second-worst offense in the entire league, averaging just 17.3 points per game.

Buffalo added WR Stefon Diggs via trade. QB Josh Allen now has Diggs, Cole Beasley, and John Brown as his receivers. Allen will seek to complete 60% of his passes during a season for the first time in his career.

Public: 96% is on the Bills -6.5.

Chicago Bears At Detroit Lions Betting Odds

Chicago Bears Vs. Detroit Lions
Bears (+135) Moneyline Lions (-155)
+3 (-110) Spread -3 (-110)
O 44.5 (-110) Total U 44.5 (-110)
Bet On Chicago Bears Vs. Detroit Lions NFL Week 1 Game at MyBookie.ag

Bears Vs. Lions Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: Ford Field, Detroit, MI
  • TV: FOX

Bears Vs. Lions Breakdown

The Bears named QB Mitch Trubisky as the starter for the season. The game opened as a pick’em and then moved to the Lions -3.

The Lions signed RB Adrian Peterson, but HC Matt Patricia hasn’t mentioned if he’s going to play on Sunday. Detroit is 9-22 in two seasons under Patricia.

Public: 51% is picking the Lions -3.

Green Bay Packers At Minnesota Vikings Betting Odds

Green Bay Packers Vs. Minnesota Vikings
Packers (+120) Moneyline Vikings (-140)
+2.5 (-110) Spread -2.5 (-110)
O 45.5 (-110) Total U 45.5 (-110)
Bet On Green Bay Packers Vs. Minnesota Vikings NFL Week 1 Game at MyBookie.ag

Packers Vs. Vikings Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: U.S. Bank Stadium, Minneapolis, MN
  • TV: FOX

Packers Vs. Vikings Breakdown

The Packers had a weird offseason and a controversial draft. When the front office selected QB Jordan Love and RB AJ Dillon with the first two picks in their 2020 draft, the NFL world went crazy.

Green Bay swept the Vikings last season as they posted a 13-3 record. The Packers have won four of their last seven visits to Minnesota.

The Vikings lost three players in the secondary defense alongside DT Linval Joseph. They recently added DE Yannick Ngakoue from Jacksonville, who had eight sacks in 2019.

Minnesota also lost WR Stefon Diggs. Rookie WR Justin Jefferson will be his replacement.

Public: 51% of the betting public is with Green Bay +2.5.

Miami Dolphins At New England Patriots Betting Odds

Miami Dolphins Vs. New England Patriots
Dolphins (+250) Moneyline Patriots (-300)
+6.5 (-110) Spread -6.5 (-110)
O 43.5 (-110) Total U 43.5 (-110)
Bet On Miami Dolphins Vs. New England Patriots NFL Week 1 Game at MyBookie.ag

Dolphins Vs. Patriots Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: U Gillette Stadium, Foxboro, MA
  • TV: CBS

Dolphins Vs. Patriots Breakdown

Without Tom Brady for the first time in 20 years, the New England Patriots will host the Dolphins as -6.5 favorites.

Eight players from the Patriots opted out of the season due to COVID concerns. No team had more opt-outs than New England.

Miami spent $230 Million in free agents in 2020, more than any team in the league. Former Patriots players like Ted Karras and Kyle Van Noy moved from New England to Miami.

Public: 51% of the betting public is with New England.

Philadelphia Eagles At Washington Football Team Betting Odds

Philadelphia Eagles Vs. Washington Football Team
Eagles (-245) Moneyline Washington (+205)
-6 (-110) Spread +6 (-110)
O 47.5 (-110) Total U 47.5 (-110)
Bet On Philadelphia Eagles Vs. Washington Football Team NFL Week 1 Game at MyBookie.ag

Eagles Vs. Washington Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: FedEx Field, Landover, MD
  • TV: FOX

Eagles Vs. Washington Breakdown

Philadelphia lost offensive linemen Brandon Brooks (Achilles) and Andre Dillard (torn bicep) for the rest of the season.

Washington’s defensive line features five first-round draft picks, including the second overall selection in 2020, Chase Young.

It’s going to be fun to watch.

Public: 60% of the betting public is with Philadelphia -6.

Las Vegas Raiders At Carolina Panthers Betting Odds

Las Vegas Raiders Vs. Carolina Panthers
Raiders (-175) Moneyline Panthers (+155)
-3 (-110) Spread +3 (-110)
O 47.5 (-110) Total U 47.5 (-110)
Bet On Las Vegas Raiders Vs. Carolina Panthers NFL Week 1 Game at MyBookie.ag

Raiders Vs. Panthers Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: Bank of America Stadium, Charlotte, NC
  • TV: CBS

Raiders Vs. Panthers Breakdown

The Panthers drafted defensive players with all their 2020 NFL draft selections. They also have a new head coach in Matt Rhule and a new QB in Teddy Bridgewater.

The Raiders lost WR Tyrell Williams for the season with a shoulder injury. Henry Ruggs III, Nelson Agholor, and TE Jason Witten are the new additions to this offense.

Public: 64% is on the Raiders -3.

Indianapolis Colts At Jacksonville Jaguars Betting Odds

Indianapolis Colts Vs. Jacksonville Jaguars
Colts (-400) Moneyline Jaguars (+325)
-8 (-110) Spread +8 (-110)
O 45 (-110) Total U 45 (-110)
Bet On Indianapolis Colts Vs. Jacksonville Jaguars NFL Week 1 Game at MyBookie.ag

Colts Vs. Jaguars Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: TIAA Bank Field, Jacksonville, FL
  • TV: CBS

Colts Vs. Jaguars Breakdown

The Colts are the favorites to win the AFC South at +110. The Jaguars are the favorites to finish with the worst regular-season record in football at +200.

The funny thing about this rivalry is Jacksonville has won four of the last six games against Indianapolis.

Public: 56% is on the Colts -8.

Cleveland Browns At Baltimore Ravens Betting Odds

Cleveland Browns Vs. Baltimore Ravens
Browns (+305) Moneyline Ravens (-365)
+7.5 (-110) Spread -7.5 (-110)
O 48.5 (-110) Total U 48.5 (-110)
Bet On Cleveland Browns Vs. Baltimore Ravens NFL Week 1 Game at MyBookie.ag

Browns Vs. Ravens Game Info

  • Date: Sunday, September 13, 2020 | 1:00 PM ET
  • Stadium: M&T Bank Stadium, Baltimore, MD
  • TV: CBS

Browns Vs. Ravens Breakdown

The Ravens suffered three losses last season, one of them was against the Cleveland Browns.

Cleveland finally invested in the offensive line. This means there are no more excuses for Baker Mayfield, Odell Beckham Jr., and company.

Baltimore spent money in their defensive line bringing Calais Campbell and Derek Wolfe in the offseason. The team parted ways with S Earl Thomas. It’s going to be interesting to see who can fill that void.

LA Chargers At Cincinnati Bengals Betting Odds

LA Chargers Vs. Cincinnati Bengals
Chargers (-175) Moneyline Bengals (+155)
-3 (-110) Spread +3 (-110)
O 43 (-110) Total U 43 (-110)
Bet On Los Angeles Chargers Vs. Cincinnati Bengals NFL Week 1 Game at MyBookie.ag

Chargers Vs. Bengals Game Info

  • Date: Sunday, September 13, 2020 | 4:05 PM ET
  • Stadium: Paul Brown Stadium, Cincinnati, OH
  • TV: CBS

Chargers Vs. Bengals Breakdown

Both the Chargers and Bengals selected a QB in the first round of the 2020 draft, but only Cincinnati named their selection the starter for the season.

We will get to see Joe Burrow in the NFL after he tossed 60 TD passes in his senior year with LSU. His welcome to the league is against one of the best defenses in the NFL, minus S Derwin James.

The Chargers will have QB Tyrod Taylor under center after 16 years with Philip Rivers in control. WR Mike Williams (shoulder) will be a game-time decision for Week 1.

Tampa Bay Buccaneers At New Orleans Saints Betting Odds

Tampa Bay Buccaneers Vs. New Orleans Saints
Buccaneers (+155) Moneyline Saints (-175)
+3.5 (-110) Spread -3.5 (-110)
O 49 (-110) Total U 49 (-110)
Bet On Tampa Bay Buccaneers Vs. New Orleans Saints NFL Week 1 Game at MyBookie.ag

Buccaneers Vs. Saints Game Info

  • Date: Sunday, September 13, 2020 | 4:25 PM ET
  • Stadium: Mercedes-Benz Superdome, New Orleans, LA
  • TV: FOX

Buccaneers Vs. Saints Breakdown

When the Buccaneers and Saints clash in the game of the week, it will be the first time two 40-year-old quarterbacks face each other in the history of the NFL.

I might add, those quarterbacks, Tom Brady, and Drew Brees have thrown more touchdowns than any other player in the league’s history.

This game will end a 74-game streak of Brady being the favorite in the regular season. The last time he was an underdog was in a visit to Green Bay in 2014.

Public: 53% of the public is going with the Saints -3.5.

Arizona Cardinals At San Francisco 49ers Betting Odds

Arizona Cardinals Vs. San Francisco 49ers
Cardinals (+255) Moneyline 49ers (-310)
+7 (-110) Spread -7 (-110)
O 49 (-110) Total U 49 (-110)
Bet On Arizona Cardinals Vs. San Francisco 49ers NFL Week 1 Game at MyBookie.ag

Cardinals Vs. 49ers Game Info

  • Date: Sunday, September 13, 2020 | 4:25 PM ET
  • Stadium: Levi’s Stadium, Santa Clara, CA
  • TV: FOX

Cardinals Vs. 49ers Breakdown

The Cardinals will be a fun team to watch with Kyler Murray in his second year while Larry Fitzgerald and DeAndre Hopkins catch everything.

The last time we saw San Francisco on the field, the Chiefs’ passing game burned them. Arizona has as many talented weapons and could look to do the same.

The San Francisco 49ers lost WR Emmanuel Sanders in free agency. FB Kyle Juszczyk and WR Deebo Samuel and considered game-time decisions for Sunday.

Public: 52% of the public is riding with Arizona +7.

Dallas Cowboys At LA Rams Betting Odds

Dallas Cowboys Vs. Los Angeles Rams
Cowboys (+255) Moneyline Rams (-310)
+7 (-110) Spread -7 (-110)
O 52 (-110) Total U 52 (-110)
Bet On Dallas Cowboys Vs. LA Rams NFL Week 1 Game at MyBookie.ag

Cowboys Vs. Rams Game Info

  • Date: Sunday, September 13, 2020 | 8:20 PM ET
  • Stadium: SoFi Stadium, Inglewood, CA
  • TV: NBC

Cowboys Vs. Rams Breakdown

The Rams lost a ton of talent on defense. LB Cory Littleton, OLB Dante Fowler Jr, CB Nickell Robey-Coleman, LB Clay Matthews, and S Eric Weddle are all gone.

The team is a little tight in the cap space, which means they won’t have the superstars they did in previous years. That will put a lot of pressure on QB Jared Goff, who threw a career-high 16 interceptions last season.

Dallas Cowboys’ Dak Prescott didn’t sign a massive contract in the offseason as expected. But he will have one of the best receiving corps in the NFL at his disposal in 2020. Amari Cooper, Michael Gallup, and CeeDee Lamb will be a nightmare for defenses.

However, keep an eye on the Cowboys offensive line. RT La’el Collins landed on IR while 29-year old Center Travis Frederick retired.

Public: 54% are on the Cowboys -3.

Pittsburgh Steelers At NY Giants Betting Odds

Pittsburgh Steelers Vs. New York Giants
Steelers (-245) Moneyline Giants (+205)
-6 (-110) Spread +6 (-110)
O 47.5 (-110) Total U 47.5 (-110)
Bet On Pittsburgh Steelers Vs. New York Giants NFL Week 1 Game at MyBookie.ag

Steelers Vs. Giants Game Info

  • Date: Monday, September 14, 2020 | 7:15 PM ET
  • Stadium: MetLife Stadium, East Rutherford, NJ
  • TV: ESPN

Steelers Vs. Giants Breakdown

The Steelers get back QB Ben Roethlisberger in what he called the best shape he’s been in a long time. Running back, James Connor is also healthy.

Pittsburgh’s defense had 38 takeaways last season, the most in the NFL. It’s hard to repeat a number like that, but they will face a Giants team that didn’t take care of the ball well in 2019.

The Giants will have new coach Joe Judge running the show. He was the New England Patriots special teams’ coach last season.

QB Daniel Jones will be on his second season in the NFL. He threw 24 touchdowns and 12 interceptions during his rookie season. His 24 TDs were the third-most by a rookie in league’s history.

Tennessee Titans At Denver Broncos Betting Odds

Tennessee Titans Vs. Denver Broncos
Titans (-135) Moneyline Broncos (+115)
-2.5 (-110) Spread +2.5 (-110)
O 41 (-110) Total U 41 (-110)
Bet On Pittsburgh Steelers Vs. New York Giants NFL Week 1 Game at MyBookie.ag

Titans Vs. Broncos Game Info

  • Date: Monday, September 14, 2020 | 10:10 PM ET
  • Stadium: MetLife Stadium, East Rutherford, NJ
  • TV: ESPN

Titans Vs. Broncos Breakdown

The Titans recently signed DE Jadeveon Clowney for a season. He’s listed as a starter on defense and will deal with a poor Broncos’ offensive line.

Denver’s LT Garett Bolles is a complete liability and RT Jawan James opted-out of the season. Their new center Lloyd Cushenberry is a rookie. Good luck dealing with Clowney.

Tennessee was the best team inside the Red Zone last season, and that helped them reach the AFC championship game. Most of the group is back, including tailback Derrick Henry who led the league in rushing yards and TDs in 2019.

The Broncos lost OLB Von Miller for the season due to an ankle injury. DT Bradley Chubb is not ready to return to the starting lineup either. He suffered an ACL injury in 2019.

Public: 63% are on the Titans.

Top Betting Sites To Bet On NFL Week 1 2021

Rank
Payment Grade
Rating
Bonus
Bet Now
Please wait ...

Check Out Our NFL Betting Guide!

Alonzo Solano

Alonzo Solano - Sports Analyst & Picks Writer

Alonzo is a Sports Analyst who has covered College Football and NFL odds for SafestBettingSites but don’t be surprised if you read him on any other sport. He’s a gaming analyst looking for winners every weekend.

Join 1,000+ Sports Bettors Who receive our experts' newsletter And never miss a winning sports pick!
Emailed weekly, unsubscribe with a single click.

This content is not available

We apologize for the inconvenience, but this content is not available.
Go Back