NFL Week 10 Expert Betting Preview | Odds & Tips

NFL Week 10 Betting Preview Odds & Picks

NFL Week 10 will have seven divisional matchups, including TNF between the Colts and Titans.

The Bengals and Steelers meeting will be played despite Pittsburgh putting four players in the COVID-reserve list, including QB Ben Roethlisberger.

Atlanta Dallas, Kansas City, and the New York Jets will be on a bye week.

We will break down the odds for Week 10’s games, along with any major injuries and line movement thus far.

NFL Week 10 Games Betting Odds

Here’s what you need to know about this week’s games, including betting odds.

Indianapolis Colts (5-3) at Tennessee Titans (6-2)

Indianapolis Colts Vs. Tennessee Titans
+113 Moneyline -133
+2 (-110) Spread -2 (-110)
O 48.5 (-110) Total U 48.5 (-110)
Bet On Indianapolis Colts Vs. Tennessee Titans NFL Week 10 Game at MyBookie.ag

Indianapolis Colts Vs. Tennessee Titans Game Info:

  • Date: Thursday, November 12, 2020 | 8:20 PM ET
  • Venue: Nissan Stadium, Nashville, TN
  • TV: FOX

The Colts dropped a two-game win streak by losing 24-10 to the Baltimore Ravens last weekend. Indy didn’t score in the second half and allowed 17 points from the Ravens.

Indianapolis TE Jack Doyle entered the league’s concussion protocol. He’s unlikely to play on Thursday.

The Titans snapped a two-game losing streak by beating the Chicago Bears 24-17. Tennessee covered as a 6.5-point favorite despite allowing 14 points in the fourth quarter.

S Dane Cruikshank (groin) and G Rodger Saffold (shoulder) are both questionable to play against the Colts.

This game opened as a PK, but the Titans are currently -2.

Houston Texans (2-6) at Cleveland Browns (5-3)

There are no odds currently at BetNow, however, you can always go and check.

Houston Texans Vs. Cleveland Browns Game Info:

  • Date: Sunday, November 15, 2020 | 1:00 PM ET
  • Venue: FirstEnergy Stadium, Cleveland, OH
  • TV: FOX

The Texans beat the Jaguars 27-25 to improve two 2-6. Both of Houston’s wins this season have been against Jacksonville. They are unlikely to have RB David Johnson for Sunday. He left the game against the Jags due to a concussion.

The Browns were in a bye week. The last time we saw them, they lost to the Raiders and scored only six points. Cleveland put quarterback Baker Mayfield on the reserve/COVID-19 list after a Browns staff member tested positive.

Cleveland opened -1, but the betting line is off the board after the Mayfield news.

Washington Football Team (2-6) at Detroit Lions (3-5)

There are no odds currently at BetNow, however, you can always go and check.

Washington Football Team Vs. Detroit Lions Game Info:

  • Date: Sunday, November 15, 2020 | 1:00 PM ET
  • Venue: Ford Field, Detroit, MI
  • TV: FOX

Washington can’t beat the NY Giants. Their last two losses have been against the G-Men. WFT quarterback Kyle Allen is expected to undergo surgery in the coming weeks on his dislocated ankle.

Head coach Ron Rivera hasn’t named a starting QB for the meeting against the Lions. QB Alex Smith played the second half of the matchup against the Giants and threw two picks.

The Lions aren’t great either. They have lost two straight against the Indianapolis Colts and Minnesota Vikings. Both results were by at least two touchdown difference.

Jacksonville Jaguars (1-7) at Green Bay Packers (6-2)

Jacksonville Jaguars Vs. Green Bay Packers
+688 Moneyline -1050
+13.5 (-110) Spread -13.5 (-110)
O 52 (-110) Total U 52 (-110)
Bet On Jacksonville Jaguars Vs. Green Bay Packers NFL Week 10 Game at BetNow

Jacksonville Jaguars Vs. Green Bay Packers Game Info:

  • Date: Sunday, November 15, 2020 | 1:00 PM ET
  • Venue: Lambeau Field, Green Bay, WI
  • TV: FOX

The Jaguars named Jake Luton the starting QB for the meeting against the Packers. Gardner Minshew continues to recover from a thumb injury. Luton completed 26 of 38 passes for 304 yards, 1 TD, and 1 INT in the 27-25 loss to Houston.

The Packers will have ten days to prepare for this game, not that they need it. Green Bay demolished the 49ers 34-17 last week.

Coach Matt LaFleur said he’s not sure on the timeline for the return of AJ Dillon (positive COVID test), Krys Barnes (positive), and Jordan Love (close contact). The team got Jamaal Williams back to practice today.

The Packers opened -14.5, but they are -13.5 at most sportsbooks.

Philadelphia Eagles (3-4-1) at NY Giants (2-7)

Philadelphia Eagles Vs. NY Giants
-170 Moneyline +148
-3 (-110) Spread +3 (-110)
O 44.5 (-110) Total U 44.5 (-110)
Bet On Philadelphia Eagles Vs. NY Giants NFL Week 10 Game at BetNow

Philadelphia Eagles Vs. NY Giants Game Info:

  • Date: Sunday, November 15, 2020 | 1:00 PM ET
  • Venue: MetLife Stadium, East Rutherford, NJ
  • TV: FOX

The Eagles remain on top of the NFC East despite not playing this weekend. The team should get back RB Miles Sanders (knee) this week. He hasn’t played since Week 6 against the Ravens.

The Giants beat Washington for the second time this season. Both New York’s wins have been against the Football Team.

WR Golden Tate is back with the Giants on Monday. Coach Joe Judge said he “anticipates him being active” this week vs. Eagles.

Philadelphia opened -3.5, but the line has moved to -3.

Tampa Bay Buccaneers (6-3) at Carolina Panthers (3-6)

Tampa Bay Buccaneers Vs. Carolina Panthers
-225 Moneyline +188
-5 (-110) Spread +5 (-110)
O 51 (-110) Total U 51 (-110)
Bet On Tampa Bay Buccaneers Vs. Carolina Panthers NFL Week 10 Game at BetNow

Tampa Bay Buccaneers Vs. Carolina Panthers Game Info:

  • Date: Sunday, November 15, 2020 | 1:00 PM ET
  • Venue: Bank of America Stadium, Charlotte, NC
  • TV: FOX

The Buccaneers had their worst performance of the season in the 38-3 loss against the New Orleans Saints. It was their first game of the season scoring less than 19 points.

Coach Bruce Arians said that Lavonte David hyperextended his knee. David should be ready to go against the Panthers.

Carolina lost to Kansas City 33-31 in a hard-fought battle. The Panthers have lost four games in a row since beating the Falcons in Week 5. RB Christian McCaffrey injured his shoulder in Sunday’s game. He’s listed day-to-day to face the Bucs.

Denver Broncos (3-5) at Las Vegas Raiders (5-3)

Denver Broncos Vs. Las Vegas Raiders
+203 Moneyline -245
+5.5 (-110) Spread -5.5 (-110)
O 52 (-110) Total U 52 (-110)
Bet On Denver Broncos Vs. Las Vegas Raiders NFL Week 10 Game at BetNow

Denver Broncos Vs. Las Vegas Raiders Game Info:

  • Date: Sunday, November 15, 2020 | 4:05 PM ET
  • Venue: Allegiant Stadium, Las Vegas, NV
  • TV: CBS

Denver has lost two of their last three games, including a 34-27 defeat against the Atlanta Falcons. Broncos rookie tight end Albert Okwuegbunam is heading to injured reserve after tearing his ACL.

The Raiders have won three of their last four games and are now in the playoffs’ contention. Las Vegas beat the Chargers 31-26 with a last-second stop in the end zone.

Las Vegas opened -3.5, but now the line has moved to -5.5.

Los Angeles Chargers (2-6) at Miami Dolphins (5-3)

Los Angeles Chargers Vs. Miami Dolphins
+130 Moneyline -150
+2.5 (-110) Spread -2.5 (-110)
O 48 (-110) Total U 48 (-110)
Bet On Los Angeles Chargers Vs. Miami Dolphins NFL Week 10 Game at BetNow

Los Angeles Chargers Vs. Miami Dolphins Game Info:

  • Date: Sunday, November 15, 2020 | 4:05 PM ET
  • Venue: Hard Rock Stadium, Miami Gardens, FL
  • TV: CBS

The Chargers have lost six of seven with Justin Herbert under center. Half of those losses have been dramatic, including a 31-26 defeat against the Raiders.

DE Joey Bosa didn’t play against Las Vegas because of a concussion. He should be back against Miami after two weeks of rest.

Miami beat Arizona 34-31 and earned their four-straight win, and second under rookie QB Tua Tagovailoa. WR Preston Williams left the fame against Cardinals with a foot injury. He’s considered day-to-day.

The line opened with Miami -2.5, and it hasn’t moved.

Buffalo Bills (7-2) at Arizona Cardinals (5-3)

Buffalo Bills Vs. Arizona Cardinals
+120 Moneyline -140
+2.5 (-110) Spread -2.5 (-110)
O 56 (-110) Total U 56 (-110)
Bet On Buffalo Bills Vs. Arizona Cardinals NFL Week 10 Game at BetNow

Buffalo Bills Vs. Arizona Cardinals Game Info:

  • Date: Sunday, November 15, 2020 | 4:05 PM ET
  • Venue: State Farm Stadium, Glendale, AZ
  • TV: FOX

The Bills took advantage of the Seahawks’ awful defense to beat Seattle 44-34 last Sunday. It was Buffalo’s third win in a row and seventh of the season. Cornerback Tre’Davious White suffered an ankle injury and is listed day-to-day.

Arizona’s loss to Miami saw QB Kyler Murray responsible for 392 of the team’s 422 total yards. Coach Kliff Kingsbury called RB Kenyan Drake (ankle) day-to-day on Monday.

The Cardinals opened -2.5, and the line hasn’t moved.

Seattle Seahawks (6-2) at LA Rams (5-3)

Seattle Seahawks Vs. LA Rams
+120 Moneyline -140
+2.5 (-110) Spread -2.5 (-110)
O 56 (-110) Total U 56 (-110)
Bet On Seattle Seahawks Vs. LA Rams NFL Week 10 Game at BetNow

Seattle Seahawks Vs. LA Rams Game Info:

  • Date: Sunday, November 15, 2020 | 4:05 PM ET
  • Venue: State Farm Stadium, Glendale, AZ
  • TV: FOX

The Seahawks are allowing a leagues’ worst 362.1 total yards per game this season. They have lost two of the last three meetings while QB Russell Wilson has turned the ball over at least three times in those losses.

The Rams are coming off a bye week after losing to the Dolphins two weeks ago. Los Angeles is unbeaten at home this season but has lost two of the last three games overall.

San Francisco 49ers (4-5) at New Orleans Saints (6-2)

San Francisco 49ers Vs. New Orleans Saints
+120 Moneyline -140
+2.5 (-110) Spread -2.5 (-110)
O 56 (-110) Total U 56 (-110)
Bet On San Francisco 49ers Vs. New Orleans Saints NFL Week 10 Game at BetNow

San Francisco 49ers Vs. New Orleans Saints Game Info:

  • Date: Sunday, November 15, 2020 | 4:25 PM ET
  • Venue: Mercedes-Benz Superdome, New Orleans, LA
  • TV: FOX

The Niners will have ten days to prepare for the Saints, but that won’t help a lot considered how decimated they are because of injuries.

The team placed Kendrick Bourne on the reserve/COVID list on Monday. He joins WR Brandon Aiyuk, WR Deebo Samuel, and T Trent Williams at the reserve/COVID-19 list.

New Orleans played their best game of the season by destroying the Buccaneers 38-3 on Sunday Night Football. It was their fifth straight win. The Saints didn’t report any injuries after beating the Bucs.

The Saints opened a touchdown favorite for this game, but the line climbed to -9.5.

Cincinnati Bengals (2-5) at Pittsburgh Steelers (8-0)

There are no odds currently at BetNow, however, you can always go back and check.

Cincinnati Bengals Vs. Pittsburgh Steelers Game Info:

  • Date: Sunday, November 15, 2020 | 4:25 PM ET
  • Venue: Heinz Field, Pittsburgh, PA
  • TV: FOX

The Bengals had a bye week last weekend. The last time we saw them on a field, they beat the Tennessee Titans 31-20.

RB Joe Mixon suffered a right foot injury against the Indianapolis Colts in Week 6. He missed the game against the Titans and is questionable to face the Steelers.

Pittsburgh is 8-0 but their 24-19 win against Dallas was far from impressive. The Steelers placed QB Ben Roethlisberger, OL Jerald Hawkins, RB Jaylen Samuels, and LB Vince Williams on the Reserve/COVID-19 List.

The line is off the board because of Roethlisberger’s COVID news.

Baltimore Ravens (2-5) at New England Patriots (8-0)

Baltimore Ravens Vs. New England Patriots
-321 Moneyline +261
-7 (-110) Spread +7 (-110)
O 43 (-110) Total U 43 (-110)
Bet On Baltimore Ravens Vs. New England Patriots NFL Week 10 Game at BetNow

Baltimore Ravens Vs. New England Patriots Game Info:

  • Date: Sunday, November 15, 2020 | 8:20 PM ET
  • Venue: Gillette Stadium, Foxboro, MA
  • TV: NBC

The Ravens needed just one good half to beat the Indianapolis Colts last weekend. The team will miss DE Calais Campbell for several weeks with a calf strain.

RB Mark Ingram is questionable to face the Patriots. He has missed the last two games with an ankle injury.

New England beat the lousy NY Jets with a last-second field goal on Monday Night Football, but they failed to cover the spread. The team hasn’t had CB Stephon Gilmore in the last two games due to a knee injury.

RB Damien Harry left the meeting against the Jets with a chest injury.

Minnesota Vikings (3-5) at Chicago Bears (5-4)

Minnesota Vikings Vs. Chicago Bears
-150 Moneyline +130
-2.5 (-110) Spread +2.5 (-110)
O 45 (-110) Total U 45 (-110)
Bet On Minnesota Vikings Vs. Chicago Bears NFL Week 10 Game at BetNow

Minnesota Vikings Vs. Chicago Bears Game Info:

  • Date: Monday, November 16, 2020 | 8:20 PM ET
  • Venue: Soldier Field, Chicago, IL
  • TV: ESPN

RB Dalvin Cook has recorded 478 yards & six TDs from scrimmage in the last two games as the Vikings beat the Packers and Lions on consecutive weeks.

Chicago has lost three games in a row, and their offensive struggles continue. The Bears rank dead last in rushing yards, and fourth-worst in points scored.

The team can switch Nick Foles with Mitch Trubisky because the backup QB is dealing with a shoulder injury and will be out for several weeks.

The Bears opened -1, but now the Vikings are sitting at -2.5.

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Alonzo Solano

Alonzo Solano - Sports Analyst & Picks Writer

Alonzo is a Sports Analyst who has covered College Football and NFL odds for SafestBettingSites but don’t be surprised if you read him on any other sport. He’s a gaming analyst looking for winners every weekend.

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