2021 Indianapolis Colts Vs. Buffalo Bills AFC Wild Card Round Betting Picks and Odds

Colts Vs. Bills Odds and Picks 2021

The Bills will host the Colts in the first game of NFL Wild Card Weekend.

Buffalo cruised into the playoffs, winning the AFC East with a 13-3 record and sitting their starters in the second half of a Week 17 victory against Miami.

The Colts stumbled in the postseason after nearly losing to the Jaguars in Week 17.

Still, they finished with an identical record to the Titans in the AFC South at 11-5, with Tennessee getting the tiebreaker. 

2021 NFL Buffalo Bills Vs. Indianapolis Colts Betting Odds

Colts vs. Bills
+245 Moneyline -300
+6½ (-113) Spread -6½ (-107)
O 51 (-110) Total U 51 (-110)
Bet On The Colts vs. Bills NFL Game At BetNow

Colts Vs. Bills Game Info

  • Date: Saturday, Jan. 9, 2021
  • Game Time: 1:05 p.m. ET
  • Venue: Bills Stadium — Orchard Park, NY
  • Where to watch: CBS

The Bills opened at -6.5 at most sportsbooks, with some briefs moves to -7 before coming back to -6.5 at most betting sites, including BetNow.eu. So far, the majority of tickets have come in on Buffalo.

The total opened at 53 points but has dropped to 51 points at just about every NFL sportsbook online. 

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Bills Vs. Colts Betting Pick

I do lean towards the Bills in this matchup, but I think the play is much better on the total.

We’ve already seen it drop from the opener of 53 points, but I think there is value on this one at under 51, as well.

For one, I don’t think the market has fully adjusted to a Bills’ defense that has played much better as the season has progressed.

They’ve faced far from elite offenses, but have held all of their previous opponents to under 30 points. And, several, to under 20 points a game.

This is especially impressive considering the negative game script these teams have faced.

From the Colts’ side, we know this offense doesn’t want to put the ball in Rivers’ hands to win games.

They want to run first and play more conservatively. They may have to air it out in this game, but that will certainly be their approach from early on.

Pick: Under 51

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Joseph Falchetti

Joseph Falchetti - Editor-in-Chief / Sports Writer & Analyst

Joe is the author of the blog, most picks, and the majority of excellent sports and casino content on SafestBettingSites. He's been mentioned on Forbes.com as a gaming analyst, and his articles have been linked by larger publications, such as the New York Times.

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